THE ESTIMATION OF 5-HYDROXYTRYPTAMINE (SEROTONIN) IN BIOLOGICAL TISSUES
نویسندگان
چکیده
منابع مشابه
The metabolism of serotonin (5-hydroxytryptamine).
Serotonin has assumed an important role as the focal point about which much current neurochemical investigation is centered. The fact that its methylated derivatives and some compounds which antagonize its action can cause hallucinations has even led to the hypothesis that some defect in the body’s ability to metabolize serotonin might be the underlying cause of schizophrenia. Yet relatively li...
متن کاملThe Metabolism of Serotonin (5-Hydroxytryptamine)
Serotonin has assumed an important role as the focal point about which much current neurochemical investigation is centered. The fact that its methylated derivatives and some compounds which antagonize its action can cause hallucinations has even led to the hypothesis that some defect in the body’s ability to metabolize serotonin might be the underlying cause of schizophrenia. Yet relatively li...
متن کاملStructure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter.
The serotonin transporter (SERT), which terminates serotonergic neurotransmission by rapid re-uptake of 5-hydroxytryptamine (5-HT) back into the nerve terminal was the subject of two studies. First, the regulatory effects of antidepressants on the expression of SERT was investigated. After chronic exposure of SERT to antidepressants, substrate transport and antidepressant binding parameters wer...
متن کاملAggregation of Blood Cells by 5-hydroxytryptamine (serotonin).
• A rapid, reproducible method of determiniEg the presence and relative amounts of adhesive and aggregated blood elements in the blood has recently been developed in this laboratory.The method involves measuring the pressure required to force blood at a constant rate through a standardized screen with multiple openings 20 micra square and 20 micra deep. This pressure has been named "screen nitr...
متن کاملThe effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.
The effects of several putative mediators of inflammatory responses on the cyclic nucleotide content of mononuclear leukocytes from human peripheral blood were investigated. Incubation of mononuclear cells with 100 muM serotonin (a maximally effective concentration) for 5 min caused a five- to eightfold increase in their content of guanosine 3',5'-monophosphate (cAMP)...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1955
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)66041-7